Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5c1485378d10b56be11089d362705f52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b02b2fafb5bb9e7027b873538a83c013 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b4c8055526000e12af4150601a4f4d7c http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_34155dba1162f12a41bdc24fab9e05ec http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f78f54ca14939aa46c042b5f8098b330 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-156 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6876 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P19-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-02 |
filingDate |
2012-04-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2013-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dca7ef11668249c9a889a3b2762bab06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9ebb879c6a080795bf1cf3338f2f7f7b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9ed6a8762cdb9d59bf95be63caed9fd6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3e848481d33d878871d5c32c52e5196d |
publicationDate |
2013-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-8404824-B2 |
titleOfInvention |
Splice variants of human IL-23 receptor (IL-23R) mRNA and use of a Δ9 isoform in predicting inflammatory bowel diseases |
abstract |
There is disclosed the cloning and identification of human IL-23R splice variants caused by alternative splicing of the IL-23R mRNA in human. Alternative mRNA forms occur through skipping one, multiple full exons or partial exons, within the IL-23R gene. A total of twenty-five (25) different IL-23R transcripts were identified. A novel exon deletion (exon 9) isoform in the interleukin 23 receptor is disclosed, denoted as Δ9. The present application also describes a quantitative assay to measure different IL-23R isoform. Detection of Δ9 isoform of IL-23R is predominantly present in colon and cervical tissues. A decrease in Δ9 is observed in inflamed colon tissues in Crohn's patients. There is disclosed a method of predicting Crohn's disease by measuring Δ9 isoform of IL-23R. |
priorityDate |
2008-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |