| abstract |
A substantially pure or isolated oligodeoxynucleotide of at least 10 nucleotides is disclosed, wherein the oligodeoxynucleotide comprised a sequence represented by either formula:n n5′N 1 N 2 N 3 T-CpG-WN 4 N 5 N 6 3′n nwherein the CpG motif is unmethylated, W is A or T, and N 1 , N 2 , N 3 , N 4 , N 5 , and N 6 are nucleotides, or the formula:n n5′RY-CpG-RY3′n nwherein the central CpG motif is unmethylated, R is A or G, and Y is C or T, as well as an oligodeoxynucleotide delivery complex and a pharmacological composition comprising the present inventive oligodeoxynucleotide, and a method of inducing an immune response by administering the present inventive oligodeoxynucleotide to a host. In some embodiments, the oligodeoxynucleotide includes the nucleic acid sequences set forth as SEQ ID NO: 137. |