| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_23a4e0c875bf1ac2b8a3b76517de6c7d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_99f08d2ba58951ee3abd1a5ce9483e9a |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-323 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0041
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-92
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0043
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0052
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-006
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5061
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0497
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0474 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-92
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61B-
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 |
| filingDate |
2011-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2013-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_607772ae8b425c6b5926c97b78732e93 |
| publicationDate |
2013-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8383354-B2 |
| titleOfInvention |
Diagnostic method for atherosclerosis |
| abstract |
The invention relates to a method of identifying/monitoring active atherosclerotic plaques associated with blood vessel walls wherein the plaques comprise activated macrophages having accessible binding sites for a ligand. The method comprises the steps of administering to a patient being evaluated for atherosclerosis an effective amount of a composition comprising a conjugate of a ligand and a chromophore capable of emitting light under predetermined conditions, allowing sufficient time for the ligand conjugate to bind to the activated macrophages, subjecting the blood vessels to the predetermined conditions using a catheter-based device, and identifying active plaques by detecting light emitted by the chromophore using a catheter-based device or by using an external imaging technique. The invention also relates to a similar method wherein a chemical moiety capable of emitting radiation is conjugated to the ligand. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8961926-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8795633-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9279813-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8916167-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010055735-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8865128-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2013101519-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8858914-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9731035-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8808998-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011044897-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9180215-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8685752-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008254499-A1 |
| priorityDate |
2003-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |