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filingDate 2011-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2013-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf6c697bfd34a51afbc83dbbb76223c5
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publicationDate 2013-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-8367408-B2
titleOfInvention Fusion partner for production of monoclonal rabbit antibodies
abstract The invention provides a rabbit-derived immortal B-lymphocyte capable of fusion with a rabbit splenocyte to produce a hybrid cell that produces an antibody. The immortal B-lymphocyte does not detectably express endogenous immunoglobulin heavy chain and may contain, in certain embodiments, an altered immunoglobulin heavy chain-encoding gene. A hybridoma resulting from fusion between the subject immortal B-lymphocyte and a rabbit antibody-producing cell is provided, as is a method of using that hybridoma to produce an antibody. The subject invention finds use in a variety of different diagnostic, therapeutic and research applications.
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