| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fe84b588303d73728aa2383ed34a78b3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7f5e957dca43c5fd49f4bdd65c5e58c4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3e0789fa3e47142bf5d2eb7f2118195e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9203de40f9ef6d4926b3487afe0e6526
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8fe725d262bfe705fd6c9ba32f5e20a3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_20279c20275f0c694a282016cf18d9d7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_53453a9f0b5f6816736727b1130d042b |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-178
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2330-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-141
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-113 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-111
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate |
2008-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2013-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e126b76d2bd4094b4f1e4000d6818d7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_791646b64e6b8652ec2b3be22e70cf2c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5d3a7480c41486c3d33ea50f24347dde
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_367a677422cfd4ece1b53ca762908bbe
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf9a67b3ce4427973e8d20fe9edfa995
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_38f427c7cb49892aae1ededf65180344 |
| publicationDate |
2013-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8367318-B2 |
| titleOfInvention |
Screening of micro-RNA cluster inhibitor pools |
| abstract |
The disclosure provides methods for inhibiting the activity of a miRNA cluster in a cell, and also for screening a cell for a phenotype(s) of interest resulting from inhibition of a miRNA cluster. The methods use a cluster pool which comprises at least one miRNA inhibitor specific for each miRNA in the miRNA cluster. MiRNA inhibitors are described that induce apoptosis in breast cancer cells and hence are useful in the treatment of breast cancer. The disclosure also provides pharmaceutical compositions which are useful for the treatment of breast cancer; methods for inducing the nuclear translocation of NF-κB in a breast cancer cell; methods for inducing the nuclear translocation of c-Jun in a breast cancer cell; method for inhibiting the nuclear translocation of NF-κB in a breast cancer cell; and methods for providing prognostic medical information relating to breast cancer progression. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9074241-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011312524-A1 |
| priorityDate |
2007-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |