http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8357301-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e5f39ad4e1fa8a39787772046fd4eeea http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_56016b399f1e1f519106e593fbf72bc5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b461e63a812431500f87fba18381e871 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-50 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01D15-08 |
| filingDate | 2010-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4c08e62c9e4c70971386b8a8df07ebf1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_080dcff56c5908832f4cea539a3b09b8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_63001320ff1a77a859f8c7df73d22718 |
| publicationDate | 2013-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-8357301-B2 |
| titleOfInvention | Chromatography equipment characterization |
| abstract | Herein is reported a method for determining whether a re-useable chromatography column packing, which is used at least for the second time in a purification step of a purification of a polypeptide, has reduced separation efficacy in said purification step of said purification of said polypeptide, comprising the following steps: a) identifying and determining the experimental data of an inert change of at least one physicochemical parameter of a mobile phase passing through said re-useable chromatography column packing, b) determining the parameters of a function of formula I by fitting the experimental data of the inert change of the physicochemical parameter of the at least second use, c) determining the difference between the experimental data of the inert change of the physicochemical parameter of the at least second use and the function of formula I with the parameters determined in step b), d) calculating the difference between the maximum value and the minimum value of the difference determined in step c) and normalizing said difference, e) determining reduced separation efficacy of said re-useable chromatography column packing when the absolute value of the difference calculated in step d) is more than 0.1. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2013281672-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9047438-B2 |
| priorityDate | 2009-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 78.