| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a9e3e603d1e744657a5184184818ebf3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ab69ee0d8325e6d10c19576c811c2f73
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_785ac2b35073f5a6d251678e6fb31b6f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_57ed5d921dee558e84c636f6fb3190e7 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10T436-143333
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-10 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6876
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-111 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53 |
| filingDate |
2011-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2012-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bc7c4908c03c0e324255e7f1849d3de0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cff2a49101d9f90806d34671075b8d36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ebca0081fcfbfa69c6f7b8d8831dbac0 |
| publicationDate |
2012-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8338185-B2 |
| titleOfInvention |
Methods of determining potency of chemically-synthesized oligonucleotides |
| abstract |
Provided herein are methods for determining potency of RNAi agents. Such methods include, but are not limited to, cell-based and cell-free assays that measure binding of an RNAi agent with Ago2 or that measure Ago2 activity in the presence of such RNAi agents. Also provided are assays that determine potency of RNAi agents by assessing their ability to compete with other RNAi agents, including control RNAi agents, for binding and/or activation of Ago2. |
| priorityDate |
2006-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |