http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8338142-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6e5ee48724bc8b7cf138d06b641a4092 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6b56fb3a208aaa5cf9d097d5972cbee1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0ddb9f3656270bc5410be3679322fead http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dee35b6cf9834af9e45ea324107642a4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b685a80e78c9cf94e414ff988d92c925 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B57-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P41-006 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-12 |
| filingDate | 2008-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2012-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e8ff0d2df6dea71888d6dd53b9d89419 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b97aa5177234b0ccaad2feb050fb3349 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e38794391784aec65b5c92a39d90ee71 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a9dd7ca9bfa02590c77852e613d285f9 |
| publicationDate | 2012-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-8338142-B2 |
| titleOfInvention | Method for producing optically active 3-aminopiperidine or salt thereof |
| abstract | The present invention relates to a method for producing an optically active 3-aminopiperidine or salt thereof. In the method, a racemic nipecotamide is stereoselectively hydrolyzed to obtain an optically active nipecotamide and an optically active nipecotic acid in the presence of an enzyme source derived from an organism, and then the optically active nipecotamide is derived into an optically active aminopiperidine or salt thereof by aroylation, Hofmann rearrangement, deprotection of the amino group and further deprotection; or the optically active nipecotamide is derived into an optically active aminopiperidine or salt thereof by selective protection with BOC, Hofmann rearrangement and further deprotection. It is possible by the present invention to produce an optically active 3-aminopiperidine or salt thereof useful as a pharmaceutical intermediate from an inexpensive and easily available starting material by easy method applicable to industrial manufacturing. |
| priorityDate | 2007-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 556.