| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6ab4fdd51d2ded6090117d6902866f4a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d1c190bd9436593db6895ba39048104f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9990b9fadf4eee24818b8e708689b8d9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8e4430be5b217f86459b629ec06f4b54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_163191b7f43211382e87233da9e2b2ad
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c45a66c6774adbb4f7270111cad1b587
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b978c365a7e6cfe36801c169273898be |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1709
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-074
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-07
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-16 |
| filingDate |
2011-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2012-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2e4bf9cda28e77545b0eee6261dfcdb4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_86a5e869deb6859ef19f40b58507ee18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1d189c356e79c3ebb3641ad3d32e0010
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4a0a31d03b81b3fa5616951ccdc67cd3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_409643ea4ae5503ab79973dccc46edc1 |
| publicationDate |
2012-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8329661-B2 |
| titleOfInvention |
Method for using HIP/PAP polypeptide composition for liver regeneration and prevention of liver failure |
| abstract |
This invention is based on the experimental finding that HIP/PAP has mitogenic and antiapoptotic effects in vitro on hepatocytes in primary culture. Moreover, HIP/PAP is a mitogenic and anti-apoptotic molecule for hepatocytcs, in vivo, during liver failure and liver regeneration. The present invention is also based on the experimental finding that HIP/PAP administration has no adverse effects in mammals. This invention concerns a pharmaceutical composition for stimulating liver regeneration in vivo including after chronic/acute liver failure, comprising an effective amount of a polypeptide comprising an amino acid sequence having 90% amino acid identity with the polypeptide consisting of the amino acid sequence starting at the amino acid residue (36) and ending at the amino acid residue (175) of sequence SEQ ID No 1, in combination with at least one physiologically acceptable excipient. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2636194-C1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8893292-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2601160-C1 |
| priorityDate |
2003-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |