| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a9d1c4aefc955b07810b76d823dd9028
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8e071d18fea054bf8d1420d483e78ed1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f6939ecbf82d5f9d4a1d51730ef65c2d |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-906 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-713
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-00 |
| filingDate |
2010-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2012-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a3bafe6bba3415220eb7c3028fffc9b8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dbffe07c08005f0ca17af26bc1ec71b1 |
| publicationDate |
2012-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8323941-B2 |
| titleOfInvention |
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1 |
| abstract |
LSD1, a homolog of nuclear amine oxidases, functions as a histone demethylase and transcriptional co-repressor. LSD1 specifically demethylates histone H3 lysine 4, which is linked to active transcription. Lysine demethylation occurs via an oxidation reaction that generates formaldehyde. Importantly, RNAi inhibition of LSD1 causes an increase in H3 lysine 4 methylation and concomitant de-repression of target genes, suggesting that LSD1 represses transcription via histone demethylation. The results thus identify a histone demethylase conserved from S. pombe to human and reveal dynamic regulation of histone methylation by both histone methylases and demethylases. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011304425-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014085613-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20150102594-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20150102595-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20150102596-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20150102597-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20150102598-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8593253-B2 |
| priorityDate |
2004-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |