http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8309337-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5098eff6d67391cd857fae0aa3174bcb http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a02ae9c574ff378f1bc4a5f157df2252 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_74a2cbfe77984e1acc7ad8a384976f00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1089 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A21D8-042 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1027 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1058 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-2417 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1048 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A21D10-00 |
| filingDate | 2011-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2012-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fd11132e20f939d56dbc37ceb3743497 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aeda4b6815a0f2ecfe593e57c2a70858 |
| publicationDate | 2012-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-8309337-B2 |
| titleOfInvention | Hybrid polypeptide of a maltogenic alpha-amylase and a cyclodextrin glucanotransferase |
| abstract | The inventors realized that the diversity generated by conventional methods may be limited by steric hindrance between amino acid residues in the three-dimensional structures of the resulting polypeptides. The steric hindrance may occur between amino acid residues at widely different positions in the amino acid sequences, e.g. between residues in two different domains of the 3D structure, and resulting polypeptides which include such steric hindrance may never be observed in the conventional recombination methods because they may be expressed in poor yields or may have poor activity or stability. The inventors developed a method to identify and alleviate such steric hindrance in the resulting polypeptides. In an alignment of the three-dimensional structures, steric hindrance is indicated when residues from two different structures are located within a certain distance. Pairs of residues at corresponding positions in the amino acid sequences are not considered, and residues close to the surface (high solvent accessibility) are considered to be less prone to steric hindrance. |
| priorityDate | 2004-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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