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filingDate 2008-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2012-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e5d2857ceaea362205eedeef3e0eb2a1
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publicationDate 2012-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-8306752-B1
titleOfInvention Method to determine transcriptional regulation pathways in organisms
abstract The invention relates to computer-implemented methods and systems for identifying regulatory relationships between expressed regulating polypeptides and targets of the regulatory activities of such regulating polypeptides. More specifically, the invention provides a new method for identifying regulatory dependencies between biochemical species in a cell. In particular embodiments, provided are computer-implemented methods for identifying a regulatory interaction between a transcription factor and a gene target of the transcription factor, or between a transcription factor and a set of gene targets of the transcription factor. Further provided are genome-scale methods for predicting regulatory interactions between a set of transcription factors and a corresponding set of transcriptional target substrates thereof.
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