Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9d6f7da1e425c8a3ef1da21e08f4c196 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_aba232d425c6d26a4f7bf096b08b203a http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b613a6eb569a2f844fa3a1783298313c http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_48eb1edee350c15fc30eeffcf1c5b6f7 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
filingDate |
2006-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2012-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_189016c29bb92fd3d75e0ca9874de2b2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f6a41171f0c42254348ad5fa4d83926e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fedadd10f5b7404b1145989777210336 |
publicationDate |
2012-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-8293477-B2 |
titleOfInvention |
Methods for modulating bone formation and mineralization by modulating KRC activity |
abstract |
This invention demonstrates that KRC molecules have multiple important functions as modulating agents in regulating a wide variety of cellular processes including bone formation and mineralization. TGF-β signaling in osteoblasts promotes the formation of a multimeric complex between KRC, Runx2, Smad3, and the E3 ubiquitin ligase, WWP1 which inhibits Runx2 function due to the ability of WWP1 to promote Runx2 polyubiquitination and proteasome-dependent degradation. Furthermore, KRC and WWP1 form a complex with RSK2 which promotes RSK2 phosphorylation and inhibits RSK2 function due to the ability of WWP 1 to promote RSK2 ubiquitination. Methods for identifying modulators of KRC activity are provided. Methods for modulating an immune response, bone formation and mineralization, and KRC-associated disorders using agents that modulate KRC expression and/or activity are also provided. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9745589-B2 |
priorityDate |
2005-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |