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filingDate 2008-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2012-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2012-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-8288108-B2
titleOfInvention Expression profiles for predicting septic conditions
abstract A rapid, safe method for predicting sepsis, or a condition similar to sepsis, in a mammal is disclosed, which comprises the following steps:n I) isolating RNA from a biological sample of a mammal; ii) labeling the isolated RNA of step I) with a detectable marker; iii) hybridizing the labeled isolated RNA of step ii) with at least one DNA of genes Seq.-ID 1 to Seq.-ID 6705 (Table 1), which is spotted onto a microarray and which is a sepsis-specific gene or gene fragment, under the reaction conditions for hybridizations; iv) quantitatively recording labeling signals of the hybridized RNA of step iii) in an expression profile; v) comparing the expression profile of step iv) with a control sample with respect to a stronger or weaker expression of genes or gene fragments which are specific for sepsis; and vi) combining the expression profile of step v) with protein- and metabolite patterns of the biological sample.
priorityDate 2005-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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