http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8273726-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_024a7a36374ae46bf96dd90073758b37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_452edf09f236371e61e3fd22a06ded78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dc064fa2a2570d8ba79d55cd84abf522 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3dd45ae79994120eb6317252a7bf5933 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9338913df262a87e8ed853ae7e7b4dff |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-695 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-695 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N55-00 |
| filingDate | 2009-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2012-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_be3c91983076fc32ffbfa5ed5d96c89d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5d686e48ccac64f0869021a77d86843e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_20ee2e831484cab85242ed7c62c2ce48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f8dd45ffb3cc86cafa9484fab160ec8b |
| publicationDate | 2012-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-8273726-B2 |
| titleOfInvention | Compositions for treating and/or preventing diseases characterized by the presence of metal ions |
| abstract | The present invention generally relates to the treatment and/or prevention of Alzheimer's disease, other neurodegenerative diseases, and/or diseases characterized by the presence of certain metal ions, by using certain compositions including organosilicon compounds. A composition of the invention may be administered to a mammal, such as a human. In some cases, the composition may include a silanol, a silandiol, a silantriol, or a cyclic organosilane, and/or be able to form a silanol, a silandiol, or a silantriol upon exposure to physiological conditions such as are found in the blood, in the stomach and/or gastrointestinal tract, or in the brain or other organ. In certain cases, the organosilicon compound may be bound to a moiety able to be transported across the blood-brain barrier into the brain, for example, an amino acid, a peptide, a protein, a virus, etc. The organosilicon compound may also be labeled (e.g., fluorescently or radioactively) in certain instances. In some embodiments, the composition, or a portion thereof, may sequester aluminum, copper, iron or other ions, for example, by electrostatically binding to the ions. The composition may also include other functionalities such as amines, certain alkyl and/or aryl moieties (including substituted alkyls and/or aryls), or hydrophobic moieties, for example, to facilitate transport of the organosilicon compound through the blood-brain barrier. |
| priorityDate | 2002-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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