| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0ab8ed59cc7abdb74f3c4734a4ae4c4a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_01983c3e7809b33d53f0fa20e524844f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_69108fc12b940ede105638f37f06080b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_481efa60cdd101d9107ff8cdfe89326c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e64e402816135f1b33c43f28bb2c3414 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01N43-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01N43-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01N43-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01N43-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-381
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-365
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-341
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-381
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-32 |
| filingDate |
2009-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2012-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_44025a6d095290bf472afb867add1c16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c7d5a924e236c22a182cd123b149e5f8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d27abc300c9795d1498e6de21859cfde
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_17980199c5f6beac94fe4bc9f086ceba |
| publicationDate |
2012-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8247443-B2 |
| titleOfInvention |
Small molecule antagonists of bacterial quorum-sensing receptors |
| abstract |
A novel small molecule antagonizes two types of acyl homoserine lactone receptors: membrane-bound and cytoplasmic. A focused library of analogs and derivatives of the original antagonist was synthesized. Analog and derivative molecules harbor a range of activities. The novel small molecule and most potent antagonist protects the eukaryote Caenorhabditis elegans from quorum-sensing-mediated killing by the bacterial pathogen Chromobacterium violaceum . The saving of C. elegans demonstrates the use of these molecules as small molecule antimicrobials. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9415040-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10807943-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8772331-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2014100242-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015042363-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9751851-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2014024707-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8568756-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011123586-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9084773-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9468624-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10526278-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017177196-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2014275232-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9045476-B2 |
| priorityDate |
2008-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |