| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_49d7635f6251d9b3dd5dbb9c0539e19e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b3b3b10767bc43ed4aa9d9ba69189913
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4ccf9fc930e0607947e4f7acb393a795
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f3c932d65bd159b8af6c284f9f814be7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_03dbd4a28db5f9da3f2809b3d31f66cc |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N1-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N1-20 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-02 |
| filingDate |
2010-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2012-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_622aa5e87c6b6e01eee85eb68c5d9263
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a7997aec421a021780a9b58233d88890
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8cedfae7cc8d166cdeaebecf9ae9fc61
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6124c86bbe1dc7cb0f681048bf30ec89 |
| publicationDate |
2012-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8241644-B2 |
| titleOfInvention |
In vitro model of latent mycobacterial infection |
| abstract |
A method of inducing latency in Mycobacterium permits preparation of an in vitro model system of latent mycobacterial infection. Latency is induced in a pure culture of Mycobacterium by exposing it to multiple stress conditions, including a low nutrient culture medium without glycerol, a low pH, a relatively high level of carbon dioxide and a relatively low gas phase oxygen level. An in vitro in vitro model of mycobacterial infection employs macrophages induced from THP1 cells which are then infected with Mycobacterium . The infected macrophages are grown under hypoxic conditions to induce latency in the mycobacteria. The in vitro model of infection is useful in evaluating compounds for activity against latent mycobacteria. |
| priorityDate |
2007-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |