http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8236946-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1ebb846def57bfa2b729490ae27225d4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dbe1d40faa1ed62003e4b49d8b278688 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J43-003 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J31-006 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J43-00 |
| filingDate | 2005-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2012-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_adfea78628622a6f391decab1be7894c |
| publicationDate | 2012-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-8236946-B2 |
| titleOfInvention | Process for the preparation of 17-0-vinyl-triflates as intermediates |
| abstract | Process for the preparation of a compound of formula (I) as defined herein by (i) triflating a ketone of formula (II) as defined herein to form a triflate of formula (III) as defined herein and (ii) reacting the compound of the formula (III) to form a compound of the formula (I) or a pharmaceutically-acceptable salt thereof. The triflating step is conducted in the presence of a base comprising a tertiary or heterocyclic amine such that the pK a of the conjugate acid at 25° C. is within the range 5.21 to 12. The base is selected from pyridine, 2,6-lutidine, N-methylmorpholine, 1,4-diazabicyclo[2.2.2]octane (DABCO), trimethylamine, triethylamine, N,N-diisopropylethylamine (DIPEA), quinuclidine and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU). |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9315541-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014064032-A1 |
| priorityDate | 2004-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 248.