| abstract |
A compound of Formula (I), or a pharmaceutically acceptable salt or solvate thereof, n nwherein,n R 1 and R 2 each independently represent H, halogen, CF 3 , C 1-3 alkyl or C 1-3 alkoxy; R 3 represents C 1-6 alkyl, C 3-6 cycloalkyl, phenyl (optionally substituted by one or more substituents each independently selected from R a ) or Het (optionally substituted by one or more substituents each independently selected from OH, oxo, or C 1-4 alkyl); R 4 represents H or C 1-3 alkyl; R 5 represents C 1-6 alkyl (optionally substituted by one or more substituents each independently selected from R b ), C 3-6 cycloalkyl (optionally substituted by one or more substituents each independently selected from oxo or OH), or Het 2 (optionally substituted by one or more substituents each independently selected from R d ); oxygen atom or 1 sulphur atom, or (c) 1 oxygen atom or 1 sulphur atom, (optionally substituted by one or more substituents each independently selected from OH, oxo or C 1-4 alkyl); and R 6 represents C 1-3 alkyl (optionally substituted by one or more substituents each independently selected from R f ), C 3-5 cycloalkyl (optionally substituted by one or more halogen), CN or halogen; where R f represents halogen or phenyl: and compositions, processes for the preparation, and uses thereof, e.g. in the treatment of endometriosis or uterine fibroids. |