http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8227571-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_adb97ae84b91a4d6eeb65d489c4a0dc8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9de29a36113ab76f0710c0740a824b61 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_32a40218af13a451d5cb407368118bdf http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_80562b6e8d99b253b981b542c66588cc |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-605 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00 |
| filingDate | 2008-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2012-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c825b20fd3c20aa40a030ffc60322ba9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_076424e962ae20f7fddb7f204d514a05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fea724f652c2d794aeb9c10e674a6f61 |
| publicationDate | 2012-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-8227571-B2 |
| titleOfInvention | Insulinotropic peptide synthesis using solid and solution phase combination techniques |
| abstract | The present invention relates to the preparation of insulinotropic peptides that are synthesized using a solid and solution phase (“hybrid”) approach. Generally, the approach includes synthesizing three different peptide intermediate fragments using solid phase chemistry. Solution phase chemistry is then used to add additional amino acid material to the third fragment which is then coupled to the second fragment and then the first fragment in solution. Alternatively, a different second fragment is coupled to the first fragment in the solid phase. Then, solution phase chemistry is then used to add additional amino acid material to a different third fragment. Subsequently, this different third fragment is coupled to the coupled first and different second fragment in the solution phase. The use of a pseudoproline in one of the fragments eases solid phase synthesis of that fragment and also eases subsequent solution phase coupling of this fragment to the other fragments. The present invention is very useful for forming insulinotropic peptides such as GLP-1(7-36) and its natural and non-natural counterparts. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10450343-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10087221-B2 |
| priorityDate | 2007-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 568.