| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b0c7f87188ef564a47e4decdf9935c19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1a331d46449cc0bf0e1e9b8bda91158f |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2310-00293
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2310-00365
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2430-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2210-0014
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2310-00353
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2210-0004
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2002-30062
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2002-30092
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2002-2817
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2-442
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2-4455
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2002-4635
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B2017-564 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B17-58 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61F2-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61F2-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61B17-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61B17-58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61F2-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61F2-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61F2-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-12 |
| filingDate |
2001-10-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2012-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ad0516f329db07acc25b8e1b9b5884e5 |
| publicationDate |
2012-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8226729-B2 |
| titleOfInvention |
Spinal fusion methods and devices |
| abstract |
Methods, devices and compositions for fusing adjacent vertebrae, and otherwise localizing bone growth, are provided. In one form of the invention, a method for fusing adjacent vertebrae includes preparing a disc space for receipt of an intervertebral disc implant in an intervertebral disc space between adjacent vertebrae, inserting the implant into the intervertebral disc space and providing an osteoinductive composition that includes an osteoinductive factor in a pharmaceutically acceptable carrier. The carrier is advantageously substantially impermeable to efflux of the osteoinductive factor and is released as the carrier is resorbed or biodegraded. Preferred carriers include a hardened, resorbable carrier, such as a calcium phosphate cement that retains at least about 50% of the osteoinductive factors greater than about 2 days. Preferred osteoinductive factors are growth factors and include bone morphogenetic proteins and LIM mineralization proteins. In alternative forms of the invention, the method may be performed without utilization of a load-bearing spinal implant by disposing the osteoinductive composition in the disc space. The method is advantageously performed on lumbar vertebrae by a posterior approach. Intervertebral fusion devices and methods for their preparation are also provided. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11452760-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10130678-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8952131-B2 |
| priorityDate |
2000-10-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |