http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8193337-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d2c8ab4633f7bf86acd6e535d0e9c337 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ebb8b1fb05e13f5e7922e38935bf2e9b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00 |
| filingDate | 2008-07-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2012-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e98813dbb38f6f6cd2902f89cfc50fb0 |
| publicationDate | 2012-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-8193337-B2 |
| titleOfInvention | Oxidation process |
| abstract | A process for the preparation of an oligonucleotide having at least one phosphate internucleotide linkage I provided. The process comprises the steps of:n a) forming a nascent oligonucleotide comprising a phosphorus (III) internucleotide linkage; and b) oxidation of the nascent oligonucleotide with aqueous iodine solution thereby to form a phosphorus (V) internucleotide linkage;n nwherein the oxidation is carried out in the presence of a base, the conjugate acid of said base having a pKa higher than the pKa of the conjugate acid of pyridine. Preferably the base is N-methylimidazole. |
| priorityDate | 2007-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 266.