| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_af1442bd83282dc3b6fb52000454bb40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ee602c630e57f59c6cfc1c1634e36064 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-08 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-17
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63 |
| filingDate |
2009-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2012-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0bb84e61ca08c940f79e33d14a77ea23 |
| publicationDate |
2012-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8192957-B2 |
| titleOfInvention |
Fibrillation-resistant insulin and insulin analogues |
| abstract |
A fibrillation-resistant insulin analogue may be a single-chain insulin analogue or a physiologically acceptable salt thereof, containing an insulin A chain sequence or an analogue thereof and an insulin B chain sequence or an analogue thereof connected by a polypeptide of 4-10 amino acids. The fibrillation-resistant insulin analogue preferably displays less than 1 percent fibrillation with incubation at 37° C. for at least 21 days. A single-chain insulin analogue displays greater in vitro insulin receptor binding than normal insulin while displaying less than or equal binding to IGFR than normal insulin. The fibrillation-resistant insulin may be used to treat a patient using an implantable or external insulin pump, due to its greater fibrillation resistance. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014145593-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9006176-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014071405-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105008395-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10195287-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3662926-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105008395-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9901622-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8501440-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11421033-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2012316107-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9163073-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023041758-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10561711-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112266414-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015083114-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013063572-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2013337250-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018047062-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10501546-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014172488-A3 |
| priorityDate |
2006-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |