| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_08e8bc0dfb42daa712057f1c02906eb4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_59c6a921f33fe0adc58c2b6177184515
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8dcf0275e6c17e77579d95897dbfe964
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_77860e44beabd168e59566d77a73f967 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-23 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-517 |
| filingDate |
2008-07-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2012-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ac6cb09a1a378934cc8c42644dc735b3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_664c65a2bead52953da966fed3435f01
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_257ce6a019c0930ada87ce5fd4afd30b |
| publicationDate |
2012-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8183249-B2 |
| titleOfInvention |
Inhibitors of AKT/PKB with anti-tumor activity |
| abstract |
The subject invention concerns materials and methods for inhibiting the Akt/PKB pathway. In one embodiment, a compound of the invention inhibits kinase activity and/or phosphorylation levels of Akt proteins. The subject invention also concerns methods for inhibiting or killing a cancer cell or other cell in which expression of an Akt protein is elevated or constitutively active, comprising contacting the cell with an effective amount of a compound of formula I. The subject invention also concerns methods for treating cancer or a tumor in a person or animal comprising administering all effective amount of a compound of formula I to the person or animal. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9993460-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9974774-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9359347-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10548876-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11135201-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11147800-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10500192-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2013034598-A1 |
| priorityDate |
2007-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |