| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e7971e09720dfcd885d83296d40ffe9d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b21f650fc35b3e1947103e89adb06f3f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4b10703cd555cc064a9432eaba3799fc |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-986
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-04 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-25 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G06G7-58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-78
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N31-00 |
| filingDate |
2008-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2012-05-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_33c324f3def07bc98c6e9dbe4820fc15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1d700852ee866dc77ec816b692ae9ff6 |
| publicationDate |
2012-05-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8180580-B2 |
| titleOfInvention |
Method for identifying a compound that modulates SIR2 protein activity |
| abstract |
The present invention relates to a method for identifying compounds that modulate the activity of sirtuin deacetylase protein family members. Compounds of the invention are identified by designing or screening for a compound which binds to at least one amino acid residue of the newly identified nicotinamide inhibition and base exchange site of Sir2 and testing the compound for its ability to modulate the activity of the Sir2 protein. Compositions and methods for preventing or treating diseases or disorders associated with Sir2 are also provided. |
| priorityDate |
2007-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |