| abstract |
The present invention relates to a polypeptide having a sequence of 7 to 20 amino acid residues, which is capable of modulating the immunosuppressive properties of a viral protein or a fragment thereof, against the host in which it is expressed (immunosuppression-modulatory sequence) when it substitutes the homologous sequence of the viral protein or fragment, the polypeptide including the minimum following consensus amino acid sequence:n nX 1 Y 9 Y 10 Y 11 CY 12 X 2 n nwherein, X 1 and X 2 are selected to impact on the immunosuppressive properties, and Y 9 to Y 12 represent variable amino acid residues. |