abstract |
The invention relates to pyrimidines suitable as substrates for O 6 -alkylguanine-DNA alkyltransferases (AGT) of formula (I) n nwherein R 1 is hydrogen, lower alkyl, halogen, cyano, trifluoromethyl or azido; R 2 is a linker; and L is a label or a plurality of same or different labels. The invention further relates to methods of transferring a label from pyrimidines of formula (I) to O 6 -alkylguanine-DNA alkyltransferases (AGT) and AGT fusion proteins. |