| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cce7fa32ace4c231c4c12b0d4f6cfb07
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f6cbb94c5423217f85d9c1e58a598905
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9627bb1dda8a4cc854b3eaf79f966cb9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eb7ce8745175865c6357f7d5fe7fccf5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7d87f91ad2278485438a8d9a286a89f0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b8d1f0167735bc3c440b22912e516bf3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_72477f9ab11c69211c3a87578566160d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_528230e06616e75390ced696387dde28 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-075 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P21-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-63
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4705
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-51 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-06 |
| filingDate |
2009-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2012-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5e5d14da9b09872bbabeb999db1aef5a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e0a26f065a70c96342397d1294d073e7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e363f7248852ead84326d4fabbe4cf2d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_554e200310822a0d2aa40490a79355c0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b95cec6b2bfbdd7615b95d089484034e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e64e5246770e0373ceba043fa9cecd4a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0ba21bd9237fd584e8252b318fb5a4db |
| publicationDate |
2012-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8173394-B2 |
| titleOfInvention |
Systems and methods for protein production |
| abstract |
The invention relates to systems and methods for producing proteins of interest. The invention employs genetically-engineered animal or plant cells that have modified protein folding or processing capacities. In one aspect, the invention features genetically-engineered cells comprising one or more recombinant expression cassettes which encode (1) a protein of interest and (2) a polypeptide that is functional in the unfolded protein response (UPR) pathway of the cells. Co-expression of the polypeptide significantly increases the yield of the protein of interest in the genetically-engineered cells. In one example, the genetically-engineered cells are animal cells, and the co-expressed polypeptide is a component or modulator of an XB1- or ATF6-mediated UPR pathway. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023122805-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022235929-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022067214-A2 |
| priorityDate |
2004-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |