| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_45cc3ab603d4e40b73340ce9d16c4c36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1f47debe7595b80c4dda38627a95e618
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0620491501d6651f404074f0d3ef4347
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a8a9982b1666c54b5bf02d6c944891e4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5ffce062dbc5418db8dae5daa1b78590
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3f5d2a6b24f2d2bfbfb45ff6909b525b |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-726 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-4788
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-553
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5041 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-567
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02 |
| filingDate |
2009-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2012-04-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_59ba26df31b23de9abdd7f46626f2e88
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_45f9a718cc2bb905dcfeae25099ea850
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5c9de0269c8cb25c3ed492a404509ebe
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b40c43b80a13d28b918f76f8984bdaee
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2afe345f790ed78c636c24ae0c737e7b |
| publicationDate |
2012-04-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8148092-B2 |
| titleOfInvention |
System and method for performing G protein coupled receptor (GPCR) cell assays using waveguide-grating sensors |
| abstract |
The present invention includes a system and method that uses optical LID biosensors to monitor in real time agonist-induced GPCR signaling events within living cells. Particularly, the present invention includes a system and method for using an optical LID biosensor to screen compounds against a target GPCR within living cells based on the mass redistribution due to agonist-induced GPCR activation. In an extended embodiment, the present invention discloses different ways for self-referencing the optical LID biosensor to eliminate unwanted sensitivity to ambient temperature, pressure fluctuations, and other environmental changes. In yet another extended embodiment, the present invention discloses different ways for screening multiple GPCRs in a single type of cell or multiple GPCRs in multiple types of cells within a single medium solution. In still yet another extended embodiment, the present invention discloses different ways to confirm the physiological or pharmacological effect of a compound against a specific GPCR within living cells. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011230359-A1 |
| priorityDate |
2005-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |