http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8114406-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c4e887826a57fe1427b69f1e112e7e80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_983ca052800fd428694efe2c6c2e86f2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_61f88efcda59d7062a4252ecf6886f58 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 |
| filingDate | 2010-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2012-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7259f7aa9f67bdfba245b970eee00584 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e7429c735988111d74610b599c0ce89a |
| publicationDate | 2012-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-8114406-B2 |
| titleOfInvention | Peptides and their utility in modulation of behavior of cells expressing α3β1 integrins |
| abstract | The present invention relates to a peptide comprising the sequence R 1 —X 1 —X 2 —X 3 —X 4 —R 2 , wherein X 1 is selected from the group consisting of N, Q, D and S; X 2 is selected from the group consisting of V, I and L; X 3 is selected from the group consisting of R and K; and X 4 is selected from the group consisting of V, I, L and F; R 1 is a hydrogen or a peptide of 1 to 6 amino acids, an acyl or an aryl group; and R 2 is a peptide of 1 to 3 amino acids, a hydroxide or an amide. The invention also relates to partial or full retro-inverso peptides comprising the above sequences The invention also relates to peptide-substrate combination comprising a substrate suitable for cell growth and the peptide of the invention, and to a vascular graft and an artificial blood vessel comprising the peptide-substrate combination. The invention also relates to a pharmaceutical composition and a peptide conjugate comprising the peptide of the invention. The invention also relates to a method of inhibiting adhesion of a cell expressing α3β1 integrin to an extracellular matrix, inhibiting α3β1-integrin-mediated cell motility, inhibiting α3β1-integrin mediated cell proliferation, promoting β3β1-integrin mediated cell proliferation and inhibiting angiogenesis utilizing the peptides of the invention. |
| priorityDate | 1999-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 124.