| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b682c921a84414ef7114a0b283fe8b13
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_26d1f12981fd7c51125b30c834f43139
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ed6a65eac49ef54ba93aae0fe563a430
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_94eb8b0cd732460763eb5607e8c6f814
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_15bce864a9da9576d9d757e16cdebd90
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f2d3599fb8f8f479dba95ca9bb504884
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_82e78e5155f4b51677e6b59d80cf80b0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_48b76d471d292f40cf4b080bb1e32ec7 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2299-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-918 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-20 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-18 |
| filingDate |
2009-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2011-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2ae717864c6a8025e9808405281d3590
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1665a062abb739e61cd0615943a735fe
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_63d15ba8b96d851ac657fc4a5594df93
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c40457e38f39beea2dac332846d197c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_368c974967f6e04f6237a7f9f68badd0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4f8f04fe60633aa857ea341cc5c7c129
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_391ea600295f65498a65908b353f5032 |
| publicationDate |
2011-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8080400-B2 |
| titleOfInvention |
Crystal structure of monoacylglycerol lipase (MGLL) |
| abstract |
A number of soluble engineered forms of MGLL that are suitable for high-throughput screening and protein crystallization, as well as a crystallized form of monoacylglycerol lipase protein (MGLL) and descriptions of the X-ray diffraction patterns are disclosed. The engineered constructs of MGLL permit the expression and purification of protein suitable for crystallography or high-throughput screening and identification of ligands, which can function as active agents to MGLL. The X-ray diffraction patterns allow the three dimensional structure of MGLL to be determined at atomic resolution so that ligand binding sites on MGLL can be identified and the interactions of ligands with MGLL amino acid residues can be modeled. Models prepared using such maps permit the design of ligands which can function as active agents which include, but are not limited to, those that function as inhibitors of MGLL. |
| priorityDate |
2008-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |