| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ef416fe4f66ebb1021cecfb0ba5ae45d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_20b9b701676ce008848c6b3be383f368
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_41c29830aac0adb459ae046397a54177
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b39f23efb32381d3953116ba870305ec |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S435-82 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-16 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-16 |
| filingDate |
2003-01-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2011-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_56344b2d3db1a6d995f8f31b3a577db1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_77db2f32f173840e2e4d749a9c7b28aa
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_71ca505ba6ec6abc18d37aed48a48add |
| publicationDate |
2011-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8071348-B2 |
| titleOfInvention |
Protein tyrosine phosphatase substrate-trapping double mutant and uses thereof |
| abstract |
The present invention provides protein tyrosine phosphatases (PTP) in which the invariant aspartate residue and the invariant glutamine residue are each replaced with a replacement amino acid residue, wherein the replacement residues together cause a reduction in catalytic rate (k cat ) of the enzyme and an increase in substrate-binding affinity (K d ) of the enzyme. The present invention further provides methods for identifying a substrate of a PTP. Also provided are kits for identifying a substrate of a PTP. Additionally, the present invention provides methods for identifying an agent that alters interaction between a PTP and a substrate of the PTP. The invention also provides methods for reducing the activity of a substrate of a PTP. |
| priorityDate |
2002-01-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |