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filingDate 2010-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2011-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2011-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-8070958-B2
titleOfInvention Separation matrix having a ligand density gradient
abstract The present invention relates to a separation matrix comprised of ligands coupled to the surfaces of a porous support, such as one or more porous particles, wherein the ligands provide at least one chemical gradient within the support. In the most advantageous embodiment, the chemical gradient is a ligand density gradient. The invention also relates to a method of providing a separation matrix comprising ligands coupled to the surfaces of a porous support, in which method at least one ligand density gradient is provided by solvent-controlled diffusion of at least one reagent into the porous support.
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