| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0a6cec8498e28e7603a699e3492f5759 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-53 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57419
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| filingDate |
2003-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2011-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3001ddb39bd815a5f79acf411a99eee1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a9c75934a2cd5f2a6384aa17254d4411
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cdd831a97dfae2d3ac6389ffdf798a46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d70d4c3955af2a12ff98735fdfd48706
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_35d0baa5e04af254f787ba083b138935
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c2f8200750ebfb417b1a0f4fb58bcdd7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1d4f16b48fc25b6e98e6132cc217005d |
| publicationDate |
2011-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8053552-B2 |
| titleOfInvention |
Neopeptides and methods useful for detection and treatment of cancer |
| abstract |
The present invention relates to compounds and methods useful for the detection and treatment of disorders associated with frameshift mutations in coding microsatellite regions. The compounds and methods are applicable in cancers, especially of DNA mismatch repair deficient (MMR) sporadic tumors and HNPCC associated tumors. The compounds disclosed in the invention are useful for detection of disorders and in therapy such as e.g. immuno-therapy. The diagnostic methods relate to diagnosis and prognostic assessment of disorders associated with frameshift polypeptides originating from frameshift mutations in coding microsatellite regions of genes based on the detection of immunological entities directed against said frameshift polypeptides in body fluids. With respect to the treatment of cancer, especially of DNA mismatch repair deficient (MMR) sporadic tumors and HNPCC associated tumors, the invention pertains to methods which use immuno therapy with combinatorial mixtures of tumor specific frameshift peptides to elicit a cytotoxic T-cell response specifically directed against tumor cells for use in prevention as well as in curative treatment of cancers and precancers. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11264117-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10055540-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8507277-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021239980-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020239937-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8541550-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8796414-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021239980-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11183286-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10847253-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10847252-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10682402-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2017340717-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8952133-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11484581-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9732131-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8470972-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2013072660-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8927691-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11168121-B2 |
| priorityDate |
2002-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |