| abstract |
A compound having the structure n nwherein R is an angiotensin receptor antagonist active group,n Y is selected from the group consisting of nn nandn n—C(R 1 H)OC(O)X((CR 12 R 13 )—(CHR 10 ) m —(CH 2 ) n —Z p —(CH 2 ) q —(CHR 11 ) r —(CR 16 R 17 ))—R 5 ; 2)n Z is —O— or —(CR 14 R 15 )—; m, n, p, q, and r are independently selected from the group consisting of 0 and 1; X is —O— or —(CR 18 R 19 )—; R 1 is selected from the group consisting of hydrogen, C 1-4 alkyl, aryl and C 1-4 alkylaryl; R 5 is —O—N═N(O)—R 3 R 4 ;n nor a pharmaceutically acceptable salt or hydrate thereof, which is useful for treating hypertension. |