| abstract |
The present invention is drawn to a 3-dimensional cell-produced scaffold construct comprising fibroblasts and the extracellular matrix that has been produced and arranged by these cells. The constructs promote the differentiation, dedifferentiation and/or transdifferentiation of cells and/or formation of tissue in vitro and in vivo, while at the same time promoting cell growth, proliferation, migration, and acquisition of in vivo-like morphology. |