| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e41651508566f0385833e1ba14a21ffd |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6869 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate |
2008-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2011-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_57ff2aa688b87bfce71b94ee602fb01f |
| publicationDate |
2011-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8017338-B2 |
| titleOfInvention |
Reversible di-nucleotide terminator sequencing |
| abstract |
The present teachings provide methods, compositions, and kits for synthesizing and sequencing nucleic acids. In some embodiments, reversible di-nucleotide compounds are employed along with cleaving reactions that remove a label and a blocking moiety. Improved sequencing efficiency is achieved by the rapid polymerase-mediated incorporation of reversible di-nucleotide compounds. In some embodiments, the di-nucleotides do not contain conventional nucleotide triphosphates, but rather employ amino acid phosphoramidate nucleotides (AAPNs). |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11117921-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10844430-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11046726-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10336785-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020033681-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10273539-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11548909-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8715938-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019147787-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10301346-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11421264-B2 |
| priorityDate |
2007-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |