| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ca32fd2a44fd326ffd027a75a57bd13f |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-88
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-10 |
| filingDate |
2009-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2011-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ab4e5ace046510add5a3d36bcba286f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4c72f3e6f764b12ff82e1262ab0c7f00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f5f4cfd5a18d76913cf7132bb94e0f33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_732f86a560137bd8e3901573ae851a51
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b1696acc8e32630ff96f22555fa536e9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_87908bbd3bde8f33ea8f545dbcd69410
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_04c6c63b5d564cb6c6a80c1d1286bc91
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b381fd2ade8ef84bea893734e751934b |
| publicationDate |
2011-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8017132-B2 |
| titleOfInvention |
Mutant CyaA polypeptides and polypeptide derivatives suitable for the delivery of immunogenic molecules into a cell |
| abstract |
The invention relates to mutant CyaA/E570Q+K860 polypeptides suitable for use as proteinaceous vectors for delivering one or more molecules of interest into a cell, in particular into a cell expressing the CD11b receptor. The invention further relates to polypeptide derivatives suitable for eliciting an immune response in a host. n The invention is more particularly directed to polypeptides derived from an adenylate cyclase protein (CyaA) either under the form of a toxin or of a toxoid, which are mutant polypeptides. Said mutant polypeptides are capable of retaining the binding activity of native CyaA to a target cell and preferably of also retaining the translocating activity of native CyaA through its N-terminal domain into target cells and furthermore have a pore-forming activity which is reduced or suppressed as compared to that of the native CyaA toxin. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9222143-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10004794-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9370564-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2012214206-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2016375119-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9708596-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010285068-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2012071393-A1 |
| priorityDate |
2009-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |