| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2dc9a78dd4b3a699238d6c136eab8d02 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-336
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-51
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-315
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-17
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-321
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3183 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01N43-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-117 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N-
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N43-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-70 |
| filingDate |
2004-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2011-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_073f9d808d98b02d8e5c762c89db3b1f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1920ec7061dadfd78bebc2330efeab84
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aeeaecb9a85afbcb54c2e4fadf43b228
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_de69d05f1bd46e003a37caf8d0533e7c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f5f01a042edea66084ef4ef9113917e0 |
| publicationDate |
2011-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8008267-B2 |
| titleOfInvention |
Stabilized immunomodulatory oligonucleotides |
| abstract |
The invention provides immunostimulatory oligonucleotides having at least one CpG dinucleotide and a secondary structure at the 5′- or 3′-end. These oligonucleotides have either reduced or improved immunostimulatory properties. The invention establishes that 5′-terminal secondary structures affect immunostimulatory activity significantly more than those at the 3′-end. The invention also provides methods for increasing or decreasing the immunostimulatory activity of a CpG-containing nucleic acid. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10588964-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11433131-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11364304-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11123294-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011229456-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10434064-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11213593-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2016201060-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10987420-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10463686-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10066230-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9974854-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10041076-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2016000906-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10596254-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10837018-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11224611-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10568898-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8202850-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8946175-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10772907-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10835550-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010183639-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011158937-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2016312225-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9844592-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11696954-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10894963-B2 |
| priorityDate |
2003-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |