| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_259045c6eba6e2c5d338b84e0a88b571 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2299-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-16 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-16 |
| filingDate |
2005-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2011-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8980e6c583a6051aaa55537cd873548c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9978885702ff9ffab54e9e9e7fdcf526
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2a88c1610715c35ca945e597c720bb7f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c45733cc0deda82d5ba85cca83f3c161
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6fdd5fd7594e5208cae10a0cfc0ebf3b |
| publicationDate |
2011-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-7998719-B2 |
| titleOfInvention |
Crystal of a phosphatase of regenerating liver 1 (PRL-1) polypeptide and method of crystallization thereof |
| abstract |
The present invention relates to a crystal structure of PRL-1 (Phospatase of Regenerating Liver) protein and a method of crystallization thereof. It has been found that the PRL-1 protein has a tertiary structure having 5 strands of beta-sheet surrounded by 6 alpha-helices and well-arranged active site with closed P-loop, and monomers form a trimer through farnesylation site in the C-terminus of said protein. Thus intra-cellular migration and membrane localization can be achieved. The said crystal structure of PRL-1 protein of the present invention is very useful for the development the agent which inhibits carcinogenesis and metastasis of the cancer. |
| priorityDate |
2004-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |