| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7e8e9c0602c4c5325568baf65a2eb74b |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6872
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0455 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-451
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-52 |
| filingDate |
2008-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2011-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_766be3b801b86986b7c962d041fdce34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3d61c10a2db821716ee3c8340eba1d2f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_10e72fcc757f33001095f73fd91cd4cf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_34a7e98e5b081db8a1c69fe9bcd18515 |
| publicationDate |
2011-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-7989630-B2 |
| titleOfInvention |
Radiotracers for imaging P-glycoprotein function |
| abstract |
P-glycoprotein transporter (P-gp) acts as a pump at the blood-brain barrier to exclude a wide range of xenobiotics (e.g., toxins, drugs, etc.) from the brain and is also expressed in a tumor in response to exposure to established or prospective chemotherapeutics (a phenomenon known as multidrug resistance). This invention concerns the preparation and use of radiotracers for imaging P-gp function in vitro and in vivo. Radiotracers of the present invention are avid substrates for P-gp and have structures based on N-Desmethyl-loperamide. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016051306-A2 |
| priorityDate |
2008-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |