| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_aea57db10fe6e572d4a54808447081e9 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-5158
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-5152
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-5154
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2035-122
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-57 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-0008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-0011
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-001
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-064
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0639 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0783
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-12 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-078
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0786
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0784 |
| filingDate |
2000-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2011-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9c0bf65bf8058bb5dd5eaf339675e1c4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_58ba84fba4862ed40748f80da68b399b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_226ba70ec5ab225e54a29e0ba1a91428
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8d544b7c38502f345d2419985287db98
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8d797a70e2520ff71b2a0bffd1eb6dc0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bd096685a426b0a4fd87293688bed191 |
| publicationDate |
2011-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-7988963-B1 |
| titleOfInvention |
Use of allogeneic cell lines to load antigen presenting cells to elicit or eliminate immune responses |
| abstract |
Novel antigen-presenting cells, including but not limited to dendritic cells, that are loaded with antigens from dead or dying cells including allogenic cell lines, and the methods for making such antigen-presenting cells are described. These loaded antigen-presenting cells induce therapeutic immune responses in humans. Such loaded antigen-presenting cells are useful in the management of cancer. Antigen-loaded dendritic cells prepared as described here can prime naïve T cells to differentiate into effector cells able to recognize multiple and/or shared tumor antigens that are expressed either on the tumor cells that are used to load the dendritic cells and/or on other tumor cells. The cytotoxic T cells generated by exposure to antigen-loaded dendritic cells prepared as described here can be used in adoptive therapy. This induction of responses against multiple antigens shared between different cells, for instance tumor cells, as described here is important as it leads to broad immune responses. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11524033-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8628762-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9233154-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2012039841-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11472856-B2 |
| priorityDate |
1999-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |