| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_07c9542186133097bd6bbb7d92393090 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-77
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-92
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-622
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-565 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6854
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6872
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2881
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2803 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 |
| filingDate |
2009-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2011-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ebd0068a4ae3a1f5e2e2f1a0f1719a2b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9ad0afe96ecbe4b189b2dca917544905
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_78d8b467cec99eb70039a1b9341b94e6 |
| publicationDate |
2011-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-7981417-B2 |
| titleOfInvention |
Blood-brain barrier targeting anti-bodies |
| abstract |
This invention provides antibodies that bind brain endothelial cell receptors resulting in endocytosis/transcytosis of the receptor and bound ligands. In some embodiments, the ligand comprises the antibody in combination with a pharmaceutically active compound and the antibody directs delivery of the compound across the blood brain barrier (BBB). The invention also provides methods of identifying endothelial cell specific antibodies by panning the library against cultured cell monolayers. The invention further allows for identifying endothelial cell receptors that bind the antibody thereby providing target receptors against which to isolate further cognate ligands and their associated transport systems and by which to identify transcytosis transporters targeted by the antibodies. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10011651-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11028156-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9629801-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8663598-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10538589-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11207461-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10144783-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11512145-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9975955-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2016208006-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11155631-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10590393-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10202467-B2 |
| priorityDate |
2006-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |