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filingDate 1999-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2011-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5d228410a0df57f76b57ae8077fb41f9
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publicationDate 2011-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-7932074-B1
titleOfInvention Multivalent human-bovine rotavirus vaccine
abstract The present invention provides vaccine compositions for protection against human rotaviral disease without significant reactogenicity. Human×bovine reassortant rotavirus comprising each of the four clinically most important VP7 serotypes of human rotavirus are combined in a multivalent formulation which provides a high degree of infectivity and immunogenicity without producing a transient febrile condition. Methods for producing an immunogenic response without producing a transient febrile condition are also provided.
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