Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e19741e967ed6c909c17813b4f9ef63e |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6803 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B20-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B20-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B15-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B15-00 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16B20-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16B15-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G06F19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G06F17-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G06F17-11 |
filingDate |
2008-04-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2011-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7dc4aaf5cd2b771582278be973717e07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d01311919e0807d25475c79149284eb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c34575abbc37cb27722c0f285cccadf6 |
publicationDate |
2011-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-7930157-B2 |
titleOfInvention |
Computational method and apparatus for predicting polypeptide aggregation or solubility |
abstract |
A prediction method for predicting the effect of an amino acid modification on the rate of aggregation (solubility) of a reference polypeptide comprising: calculating the difference in hydrophobicity (ΔHydr) between the reference polypeptide and a modified polypeptide, calculating the difference in β-sheet propensity (ΔΔG coil-α +ΔΔG β-coil ) between the reference polypeptide and modified polypeptide, calculating the difference in charge (Δ Charge) between the reference polypeptide and modified polypeptide, and calculating: [x*ΔHydr]+[y*(ΔΔG coil-α +ΔΔG β-coil )]−[z*ΔCharge], wherein x, y and z are scaling factors. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008262742-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8849578-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8155888-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010261882-A1 |
priorityDate |
2003-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |