| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7b94d2715cda37c1f23e48f9f4f23422 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2818 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 |
| filingDate |
1998-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2011-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6035a45f8566890c67b952e59ab56522
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d7568da9a2d2a3a3f1b814053540645f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_16e765e5a0363353859a4b4884b1d376
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ae0da4015c24071c882904ae6c22bb1c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ae5fd6611dda59ac07e3c3b986d7e72 |
| publicationDate |
2011-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-7927595-B1 |
| titleOfInvention |
Methods for downregulating CCR5 in T cells with anti-CD3 antibodies and anti-CD28 antibodies |
| abstract |
Methods for modulating HIV-1 fusion cofactor expression by manipulating an accessory molecule on the surface of T cells, such as CD28, are described. The invention encompasses methods for modulating HIV-1 fusion cofactor expression by stimulating or inhibiting one or more intracellular signals which result from ligation of a surface receptor on a T cell which binds a costimulatory molecule. In one embodiment, expression of an HIV-1 fusion cofactor, such as CCR5, is downregulated by stimulating a CD28-associated signal in the T cell. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10294454-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10414140-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11512288-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9683097-B1 |
| priorityDate |
1997-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |