| abstract |
The invention relates to methods to prevent, treat, ameliorate or slow the progression of one or more of a blood cell deficiency, unwanted inflammation, allergy, immune suppression condition, immunosenescence, autoimmune disorder, infection, neurological disorder, cardiovascular disorder, pulmonary disorder, trauma, hemorrhage, bone fracture or unwanted or excess bone loss with steroid compounds containing carbon-carbon double bonds within the fused four-ring system such that the steroid compounds are unsaturated. The unsaturated steroid compounds include 3,16α,17β-trihydroxy-7-acetoxy-androst-1,3,5(10),6-tetraene, 3,16α,17β-trihydroxy-7-methoxy-androst-1,3,5(10),6-tetraene, 3,17β-dihydroxy-7-acetoxy-16α-fluoro-androst-1,3,5(10),6-tetraene, 3,17β-dihydroxy-7-methoxy-16α-fluoro-androst-1,3,5(10),6-tetraene, 3,17β-dihydroxy-7,16α-diacetoxy-androst-1,3,5(10),6-tetraene and 3,17β-dihydroxy-7-methoxy-16α-acetoxy-androst-1,3,5(10),6-tetraene. |