| abstract |
Pyrazoloamides are provided which are phosphonate and phosphinate glucokinase activators that are useful in treating diabetes and related diseases and have the structure n nwhereinn n nis a pyrazoyl ring;n R 4 is —(CH 2 ) n —Z—(CH 2 ) m —PO(OR 7 )(OR 8 ),n —(CH 2 ) n Z—(CH 2 ) m —PO(OR 7 )R 9 , or —(CH 2 ) n Z—(CH 2 ) m —PO(R 9 )(R 10 ); n R 5 and R 6 are independently selected from H, alkyl and halogen; Y is R 3 (CH 2 ) s , wherein R 3 is aryl , s is 0, X is a bond; and n, Z, m, R 4 , R 5 , R 6 , and R 7 are as defined herein;n nor a pharmaceutically acceptable salt thereof. |