http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7893269-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_55ad301cc7a70e081404f170702e471a |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-81 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-02 |
| filingDate | 2005-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_401d20bb724348bffa0c6d1198e6641a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_12b261f21590d64647ae543924503113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f743e02d772f91c222fc6a97378a7a0c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_55ecd17602dcb5afa1b72e89676f8f21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f1857c163e24f0a82e2106b70915c9f6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_98cce952b4ea6a4490ad61df21228eda http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d6e0d9780490f024b54a4bd684a611b0 |
| publicationDate | 2011-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-7893269-B2 |
| titleOfInvention | Process for the manufacture of 3-hydroxy-N-alkyl-1-cycloalky1-6-alkyl-4-oxo-1,4-dihydropyridine-2-carboxamide and its related analogues |
| abstract | The present invention relates to a novel process for the preparation of 1-alkyl or 1-cycloalkyl derivatives of 3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxamide of formula (I). The process includes reacting an amine R 2 NH 2 with a compound of formula (II) in a solution of metal hydroxide in water to give a compound of formula (III). Subsequent reaction of the compound of formula (III) with an acid chloride formation reagent in an inert solvent gives compounds of formula (I). The acid chloride formation reagent is selected from oxalyl chloride and dimethylformamide, dimethylchloromethylene-ammonium chloride and thionyl chloride and dimethylformamide. If desired, a compound of formula (I) where R 5 is hydrogen may be formed when an intermediate substituent is used wherein R 5 is an alcohol protective group removable by catalytic hydrogenation. |
| priorityDate | 2004-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 294.