http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7893088-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b6042509de7544921c96de43b9da1438 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-00 |
| filingDate | 2007-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4ef3bfa095d3b6dc566a2de365cf400e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4e9c228246a1192ac0b58cc6a7ef83bd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf7f1d50d11178b2b9900446e11b2ef6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_984f0f140a90ccc9b5e229d603a56618 |
| publicationDate | 2011-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-7893088-B2 |
| titleOfInvention | 6-substituted isoquinoline derivatives |
| abstract | The present invention relates to 6-substituted isoquinoline derivatives having the general Formula I n nwherein X is O, S or NH; Y is OH or NH 2 ; m is 0, 1 or 2; n is 0 or 1; o is 0 or 1; R 1 is H, when Y is NH 2 ; or R 1 is H, (C 1-4 )alkyl or halogen, when Y is OH; R 2 and R 3 are independently H, (C 1-4 )alkyl or halogen; R 4 is H or (C 1-6 )alkyl, optionally substituted with halogen, (C 3-7 )cycloalkyl, (C 6-10 )aryl or a saturated 5- or 6-membered heterocyclic ring comprising 1-3 heteroatoms independently selected from O, S and N, the (C 6-10 )aryl and heterocyclic ring being optionally substituted with (C 1-4 )alkyl, (C 1-4 )alkyloxy or halogen; R 5 is H or (C 1-4 )alkyl; or a pharmaceutically acceptable salt thereof, with the proviso that the compounds of Formula I wherein X is O, Y is OH , n is 0 and m+o=2 are excluded, to pharmaceutical compositions comprising the same, as well as to the use of said 6-substituted isoquinoline derivatives for the preparation of a medicament for the treatment of ROCK-I related disorders such as glaucoma, hypertension and atherosclerosis. |
| priorityDate | 2006-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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